Ọgwụ Nchekwa Aspirin

Aspirin, dị ka ọgwụ mgbochi platelet dị irè, na-eji ya eme ihe nke ukwuu n'igbochi na ọgwụgwọ nke ọrịa obi na akwara ụbụrụ. Nnyocha ahụ chọpụtara na ụfọdụ ndị ọrịa enweghị ike igbochi ọrụ platelet nke ọma n'agbanyeghị ojiji aspirin dị obere ogologo oge, ya bụ, iguzogide aspirin (AR). Ọnụego ya dị ihe dị ka 50%-60%, e nwekwara ọdịiche agbụrụ doro anya. Glycoprotein IIb/IIIa (GPI IIb/IIIa) na-arụ ọrụ dị mkpa na nchịkọta platelet na thrombosis dị oke njọ na ebe mmerụ ahụ vaskụla. Ọmụmụ ihe egosila na polymorphisms mkpụrụ ndụ ihe nketa na-arụ ọrụ dị mkpa na iguzogide aspirin, na-elekwasị anya karịsịa na polymorphisms mkpụrụ ndụ ihe nketa GPIIIa P1A1/A2, PEAR1 na PTGS1. GPIIIa P1A2 bụ mkpụrụ ndụ ihe nketa bụ isi maka iguzogide aspirin. Mgbanwe na mkpụrụ ndụ ihe nketa a na-agbanwe nhazi nke ndị nnata GPIIb/IIIa, na-ebute njikọ dị n'etiti platelet na nchịkọta platelet. Nnyocha ahụ chọpụtara na ugboro ole P1A2 alleles dị n'ime ndị ọrịa na-anaghị anabata aspirin dị elu karịa nke ndị ọrịa nwere mmetụta aspirin, ndị ọrịa nwere mgbanwe homozygous P1A2/A2 enweghịkwa ezigbo ọrụ mgbe ha ṅụchara aspirin. Ndị ọrịa nwere alleles P1A2 alleles a na-eme stenting nwere ọnụego thrombotic subacute nke dị okpukpu ise karịa nke ndị ọrịa ụdị homozygous P1A1, nke chọrọ doses dị elu nke aspirin iji nweta mmetụta anticoagulant. Aleles PEAR1 GG na-aza aspirin nke ọma, ndị ọrịa nwere AA ma ọ bụ AG genotype ndị na-aṅụ aspirin (ma ọ bụ jikọta ya na clopidogrel) mgbe etinyere stent nwere nnukwu infarction na ọnwụ. Age genotype PTGS1 GG nwere nnukwu ihe egwu nke iguzogide aspirin (HR: 10) na nnukwu ihe omume obi (HR: 2.55). AG genotype nwere obere ihe egwu, a kwesịkwara ilebara anya nke ọma na mmetụta nke ọgwụgwọ aspirin. AA genotype na-enwe mmetụta karịa aspirin, ihe omume nke ihe omume obi dịkwa obere. Nsonaazụ nchọpụta nke ngwaahịa a na-anọchite anya naanị nsonaazụ nchọpụta nke mkpụrụ ndụ ihe nketa PEAR1, PTGS1, na GPIIIa mmadụ.