Ọgwụ Nchekwa Aspirin

Aspirin, dị ka ọgwụ mgbochi platelet dị irè, bụ nke a na-ejikarị eme ihe na mgbochi na ọgwụgwọ nke ọrịa obi na ụbụrụ cerebrovascular. Nnyocha ahụ chọpụtara na ụfọdụ ndị ọrịa achọpụtala na ha enweghị ike igbochi ọrụ nke platelet n'ụzọ dị irè n'agbanyeghị iji aspirin na-adị ogologo oge, ya bụ, nguzogide aspirin (AR). Ọnụego ahụ bụ ihe dịka 50%-60%, ma enwere ọdịiche dị n'etiti agbụrụ. Glycoprotein IIb/IIIa (GPI IIb/IIIa) na-arụ ọrụ dị mkpa na nchịkọta platelet na nnukwu thrombosis na saịtị nke mmerụ ahụ. Nnyocha egosiwo na mkpụrụ ndụ polymorphisms na-ekere òkè dị mkpa na nguzogide aspirin, na-elekwasị anya na GPIIa P1A1/A2, PEAR1 na PTGS1 gene polymorphisms. GPIIa P1A2 bụ isi mkpụrụ ndụ ihe nketa maka iguzogide aspirin. Mgbanwe dị na mkpụrụ ndụ ihe nketa a na-agbanwe nhazi nke ndị na-anabata GPIIb/IIIa, na-ebute njikọ n'etiti platelet na nchịkọta platelet. Nnyocha ahụ chọpụtara na ugboro ole P1A2 alleles na ndị ọrịa na-eguzogide ọgwụ aspirin dị elu nke ukwuu karịa nke ndị ọrịa nwere mmetụta aspirin, na ndị ọrịa nwere P1A2/A2 mutations homozygous nwere mmetụta na-adịghị mma mgbe ha nwesịrị aspirin. Ndị ọrịa nwere mutant P1A2 alleles na-enweta stenting nwere mbelata ihe omume thrombotic nke ji okpukpu ise karịa nke ndị ọrịa anụ ọhịa P1A1 homozygous, na-achọ ọgwụ aspirin dị elu iji nweta mmetụta anticoagulant. PEAR1 GG allele na-anabata aspirin nke ọma, yana ndị ọrịa nwere AA ma ọ bụ AG genotype na-ewere aspirin (ma ọ bụ jikọtara ya na clopidogrel) mgbe etinyere stent nwere nnukwu infarction myocardial na ọnwụ. PTGS1 GG genotype nwere nnukwu ihe ize ndụ nke nguzogide aspirin (HR: 10) yana nnukwu ihe omume nke obi (HR: 2.55). The AG genotype nwere ihe ize ndụ na-agafeghị oke, na ekwesịrị itinye nlezianya anya maka mmetụta ọgwụgwọ aspirin. AA genotype na-enwe mmetụta nke ọma na aspirin, na ọnọdụ nke ihe omume obi na-adị ntakịrị. Nsonaazụ nchọpụta nke ngwaahịa a na-anọchi anya naanị nsonaazụ nchọpụta nke mkpụrụ ndụ ihe nketa PEAR1, PTGS1 na GPIIa.