Ngwá agha ọhụrụ maka Nchọpụta Agwọ na Ngwọta Ọhụrụ: TNGS Ọgbọ (TNGS) jikọtara ya na igwe na-amụ maka ọrịa ụrọ
Nkwupụta Akwụkwọ: CCA: Ihe nchoputa dabere na TNGS na igwe mmụta, nke dabara adaba maka ndị nwere oke ụkwara nta na Tubercaless.
Aha Nta: Tubercaless-ezubere iche na-esote ụzọ: atụmatụ nyocha nke ultra-enweghị atụ maka paucic purnonics na tubulary tubulary na tubulary tubulary.
Oge oge: "Chọọchị Chicacacta"
Ọ bụrụ: 6.5
ITbọchị Mpempe: Jenụwarị 2024
Jikọtara ya na Mahadum nke Mahadum nke sayensị na Beijing obi ụlọ ọgwụ na-eme ihe ngosi nke Trubercositio (TNGS) na usoro mmụta na igwe, nke nyere ultra-elu Nchọpụta nchọpụta maka ụma na nje ole na ole na TuberCaless na-eme, ma ọ bụrụ na usoro ọgwụgwọ ọhụụ maka usoro ọgwụgwọ Nchọpụta ụdị ụyọkọ ụkwara nta, ma nyekwa aka chọpụtara nchọpụta ahụ nke ọma, nyocha ọgwụ na ọgwụgwọ nke ụkwara ụyọkọ. N'otu oge ahụ, enwere ike iji ya na plasma CFDNA dị ka ụdị ọrụ nlele kwesịrị ekwesị maka nlele nke ụlọ ọgwụ na nyocha nke TBM.
N'ime ọmụmụ a, a na-eji sample na sroprossininal syplininal samplic compress abụọ, nke ụlọ ọrụ nyocha ụlọ nyocha nke nchọpụta nke ọrịa ụrọ Tuberclostic na-achọpụta ihe nlereanya nchoputa nlereanya. A na-ebu ụzọ ebu ụzọ leba anya na ọdọ mmiri nyocha nke a na-ahụ anya nke akpa ego maka mycobacterium. Mgbe ahụ, nke sitere na TB-TNGS SequenceNding Data, a na-eji mkpebi mkpebi na-eme ihe na-eme ihe na-akwado usoro ọzụzụ dị na ntanetị, na nchọgharị ahụ nyochara ihe nlele nke plasma smart. A na-ewetara ọnụego nke a nwetara n'ime ule ule abụọ nke nyocha nyocha nke nyocha, yana arụmọrụ nyocha nke onye na-amụ ihe na-enyocha site na ROC usoro. N'ikpeazụ, a chọpụtara ihe nlereanya nke ụkwara nta.
Fig 1 atụmatụ eserese nke atụmatụ nyocha
Nsonaazụ: Dabere na ntụgharị nke CSF DNA (AUS = 0.974) Mmetụta na nkọwapụta nke Plasma Sample bụ 82.61% na 86.36%. Na nyocha nke 44 ejikọtara ọnụ nke plasma cldna na cerbrossinal Drinto site na ihe omumu a nwere otutu ihe omumu a, na udiri ihe bu 95.45% (42/44). N'ime ụmụaka nwere atụmatụ nchọpụta nke ọmụmụ a bụ ihe na-emetụta nsonaazụ nchọpụta mmiri nke XPRET site na otu ndị ọrịa (28.57% VS 15.38%).
Fig.
Fig 3 Nchọpụta nke nyocha
Nkwubi okwu: usoro nchọpụta nke ụyọkọ nke ụyọkọ na-eme ka ọ bụrụ n'ọmụmụ ihe a, nke nwere ike ịnye ngwaọrụ nchọpụta na ndị ọrịa nchọngwụ kachasị elu maka ọrịa oligobacillillary (ọdịbendị na-adịghị mma). Nchọpụta nke ụyọkọ tuberculosis dabere na plasma cfdna nwere ike ịbụ ụdị ihe atụ dabara adaba maka ọrịa na-arụ ọrụ na-arụ ọrụ na-arụ ọrụ na-arụ ọrụ maka ndị ọrịa na-enyo enyo na-eche banyere ụrọ ụbụrụ ụbụrụ.
Njikọ mbụ: https://www.scirect.com/science/artis/pii/SIPII/SION9898123004990 Via% 3dihub
Ntughari obere mkpirisi nke Macro & Micro-Truberculosis usoro nchọta
N'ihi ọnọdụ nlele nke ndị ọrịa Tuberculosis na mkpa dị iche iche, ule Macro & Nnyocha Ngs maka mmịpụta mmanya na-egbu egbu site na nyocha nke mkpụrụokwu. Ngwaahịa ahụ na-ekpuchi nchọpụta ọrịa tiberculosis ngwa ngwa, ọgwụ na-ebuso ọrịa nke ụym, na-egosi nchọpụta mycobactosis nke nje nje na Tuberculosis na-adịghị mma, wdg.
Kins chọpụtara maka ụkwara nta na mycobacteria:
| Ihe mba | aha | Ihe Nnwale Nnwale ngwaahịa | ụdị atụ | Ihe nlere |
| HWT-3012 | Nleta nlele | Ejiri ya na ọgwụgwọ mmanya na-egbu egbu nke sputum samples, enwetala nọmba ndekọ mbụ, igwe na-eme nke mbụ, igwe na-eme sutog 20230047. | sputum | |
| HWT-NGS-P00021 | Quarcomm quation Kit maka ụyọkọ ụyọbụ | Nchọpụta nnụnụ na-abụghị nke a na-eme (a na-eme) Ihe nlere nke ndi mmadu na-enyo enyo ma obu ihe nlere na-achuputa oria site na otutu ihe omumu ma obu ihe omuma nke otutu oria ogwu enyere. | Ọbara akwara, alveolage mmiri, hydrottorax na ASCETIT, ihe nlele anya, mmiri cerebrupnins. | Ọgbọ nke abụọ |
| HWT-NGS-T001 | MyCobactecritium pịnye na Nchọpụta ọgwụ na-eduhie Kit (Ampolification Sequence) | Nyocha MyCobacterium, gụnyere MTBC na 187 NTM;Nchọpụta ọgwụ mgbochi nke mycobactosis na-ahụ maka mkpuchi 13 ọgwụ na 16 isi saịtị ndị na-eguzo afọ. | Sputum, alveolar lavage lavage, hydrottorax na ASCETHE, ihe nlele anya, mmiri cerebrupnins. | Nke abụọ / nke atọ ọgbọ |
Isi mmalite: HWT-NGS-T001 MyScobacterium dee na Nchọpụta ọgwụ na-eduhie Kit (usoro Ampoction)
Nmkpọ Okwu mmalite
Ngwaahịa a dabere na usoro nke abụọ na nke abụọ kọwara na onye nduzi ọgwụgwọ TB, Macrolides na nduzi NTM, ebe nrụpụta ọgwụ na-ekpuchi saịtị ndị metụtara ọgwụ na Onye mycbostrosis Tubercuctosis tubercosis nwere ike itinye mkpụrụ ndụ mkpụrụ ndụ na usoro ọgwụ ndị ọzọ na saịtị ndị ọzọ dabere na nyocha na ọnụ ọgụgụ nke ihe ndi ozo di elu na ulo na ndi ozo.
A na-ejikọ njirimara dabere na NTM ndị a chịkọtara na NTM Journal nke Chinese Jourcousis bipụtara na ọrịa iku ume na nkwekọrịta nke ndị ọkachamara. Ndị a mere emepụtaghị prilis nwere ike ịtụle, usoro na-agagharị ma na-akọkwa ihe karịrị ụdị NTM.
Site na teknụzụ Activation PcRlition PcRlietion Pclution, mkpụrụ ndụ ihe nketa mkpụrụ ndụ mycobactoctium nke na-eguzogide ọgwụ mycom, na amplicon jikọta mkpụrụ ndụ mkpụrụ ndụ a ka enwetara. Enwere ike idobere ngwaahịa ndị a na-emepụta n'ọnwa ma ọ bụ nke atọ-site na ọkwa nke atọ na ọgbọ niile na usoro dị iche iche na-enweghị isi iji nweta ozi nke mkpụrụ ndụ ihe nke atọ. Site na iji ya tụnyere ebe a ma ama na ebe a na-eme ihe (gụnyere onye Mycobactosis Tubercuctosis TUbercuctosis na-emegide nguzogide ọgwụ), mmụba metụtara ọgwụ ọjọọ na-ekpebisi ọgwụ ike. Jikọtara ya na usoro ọgwụgwọ nke Macro & Micro-Ngwọta, nsogbu nke arụmọrụ aclum stutud (ugboro iri na-eguzogide nchọpụta ihe ọ bụla ozugbo etinyere ya na usoro clitical sputum.
Ihe nchọpụta ngwaahịa
34mkpụrụ ndụ ndị metụtara ọgwụ18mgbochi ụkwara ume na6Achọpụtara ọgwụ NTM, na-ekpuchi297Saịtị na-agbanwe agbanwe; Testdị Mycobacterium ụyọkọ190Achọpụtala ụdị NTM.
Tebụl 1: Ozi banyere 16 + 6 ọgwụ + 190 + NTM
Uru
Ike Clinical: Enwere ike ịchọpụta ihe nlere anya na-egbu egbu na-enweghị omenaala.
Ọgwụ nnwale ahụ dị mfe: Oge mbụ nke ọrụ Aclification dị mfe, a na-emecha akwụkwọ ọba akwụkwọ n'ime awa 3, nke na-eme ka arụmọrụ dị mma.
Usoro nguzogide na nke ogwu: Ikpuchi saịtị na-eguzogide na NTM, nke bụ isi ihe na-egbochi ya, na-akwado sọftụwia nyocha, yana ịkọwapụta nyocha nyocha na otu Pịa.
Ntụkọta: Ndakọrịta Ngwaahịa, na-emegharị na OLM na MGI / NTTI / NTT.
Nkọwapụta ngwaahịa
| Koodu ngwaahịa | aha | Nlọ | nkowa |
| HWT-NGS-T001 | Pombobocractium nke mycobacterium na-agbanwe na-eguzogide ọgwụ na-agbanwe ọgwụgwọ (usoro ampox) | Ont, MGI, Salsi Pro | 16 / 96rxn |
Oge post: Jan-23-2024