Clostridium Difficile Glutamate Dehydrogenase (GDH) na Toxin A/B

Clostridium difficile (CD) bụ bacillus anaerobic gram-positive, nke bụ osisi nkịtị n'ahụ mmadụ. A ga-egbochi osisi ndị ọzọ ịmụba n'ihi ọgwụ nje ejiri mee ihe n'ọtụtụ buru ibu, CD na-amụkwa n'ahụ mmadụ n'ọtụtụ buru ibu. A na-ekewa CD n'ime ụdị ndị na-emepụta toxin na ndị na-anaghị emepụta toxin. Ụdị CD niile na-emepụta glutamate dehydrogenase (GDH) mgbe ha na-amụ nwa, naanị ụdị toxin na-akpata ọrịa. Ụdị ndị na-emepụta toxin nwere ike imepụta nsí abụọ, A na B. Toxin A bụ enterotoxin, nke nwere ike ibute mbufụt nke mgbidi eriri afọ, ntinye mkpụrụ ndụ, mmụba nke permeability nke mgbidi eriri afọ, ọbara ọgbụgba na necrosis. Toxin B bụ cytotoxin, nke na-emebi cytoskeleton, na-akpata pyknosis cell na necrosis, ma na-emebi mkpụrụ ndụ parietal eriri afọ ozugbo, na-ebute afọ ọsịsa na pseudomembranous colitis.