Clostridium siri ike Glutamate Dehydrogenase (GDH) na Toxin A/B

Clostridium difficile (CD) bụ bacillus anaerobic gram-positive, nke bụ ahịhịa nkịtị na ahụ mmadụ. A ga-egbochi osisi ndị ọzọ ịmụba n'ihi ọgwụ nje ndị a na-eji na oke doses, na CD na-amụba n'ime ahụ mmadụ n'ọtụtụ buru ibu. A na-ekewa CD n'ime ụdị ndị na-emepụta nsi na ndị na-adịghị emepụta nsi. Ụdị CD niile na-emepụta glutamate dehydrogenase (GDH) mgbe ha na-amụpụta, na naanị ụdị nsị na-akpata. Ụdị nsị na-emepụta ihe nwere ike ịmepụta nsị abụọ, A na B. Toxin A bụ enterotoxin, nke nwere ike ime ka mbufụt nke mgbidi eriri afọ, ntinye cell, mmụba nke mgbidi eriri afọ, ọbara ọgbụgba na necrosis. Toxin B bụ cytotoxin, nke na-emebi cytoskeleton, na-ebute cell pyknosis na necrosis, na-emebikwa mkpụrụ ndụ intestinal parietal ozugbo, na-ebute afọ ọsịsa na pseudomembranous colitis.