Clostridium siri ike Glutamate Dehydrogenase (GDH) na Toxin A/B

Clostridium difficile (CD) bụ bacillus anaerobic gram-positive, nke bụ ahịhịa nkịtị na ahụ mmadụ.A ga-egbochi osisi ndị ọzọ ịba ụba n'ihi ọgwụ nje ndị a na-eji n'ọtụtụ buru ibu, na CD na-emepụtaghachi n'ime ahụ mmadụ n'ọtụtụ buru ibu.A na-ekewa CD ka ọ bụrụ ụdị ndị na-emepụta nsi na ndị na-adịghị emepụta nsí.Ụdị CD niile na-emepụta glutamate dehydrogenase (GDH) mgbe ha na-amụpụta, na naanị ụdị nsị na-akpata.Ụdị nsị na-emepụta ihe nwere ike ịmepụta nsị abụọ, A na B. Toxin A bụ enterotoxin, nke nwere ike ime ka mbufụt nke mgbidi eriri afọ, ntinye cell, mmụba nke mgbidi eriri afọ, ọbara ọgbụgba na necrosis.Toxin B bụ cytotoxin, nke na-emebi cytoskeleton, na-ebute cell pyknosis na necrosis, na-emebikwa mkpụrụ ndụ intestinal parietal ozugbo, na-ebute afọ ọsịsa na pseudomembranous colitis.