Mgbanwe Mkpụrụ Ndụ Ihe Mgbakwụnye BCR-ABL nke Mmadụ

Ọrịa myelogenousleukemia na-adịghị ala ala (CML) bụ ọrịa clonal dị njọ nke mkpụrụ ndụ hematopoietic. Ihe karịrị 95% nke ndị ọrịa CML na-ebu chromosome Philadelphia (Ph) n'ime mkpụrụ ndụ ọbara ha. Isi ihe kpatara CML bụ ndị a: A na-emepụta mkpụrụ ndụ BCR-ABL site na ntụgharị n'etiti abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) na ogwe aka ogologo nke chromosome 9 (9q34) na mkpụrụ ndụ ihe nketa breakpoint cluster (BCR) na ogwe aka ogologo nke chromosome 22 (22q11); protein fusion nke mkpụrụ ndụ ihe nketa a na-etinye na ya nwere ọrụ tyrosine kinase (TK), ma na-eme ka ụzọ mgbaama ya dị n'okpuru (dịka RAS, PI3K, na JAK/STAT) kwalite nkewa mkpụrụ ndụ ma gbochie apoptosis mkpụrụ ndụ, na-eme ka mkpụrụ ndụ gbasaa n'ụzọ dị njọ, ma si otú a na-akpata CML. BCR-ABL bụ otu n'ime ihe ngosi nchọpụta dị mkpa nke CML. Mgbanwe dị iche iche nke ọkwa akwụkwọ ya bụ ihe ngosi a pụrụ ịtụkwasị obi maka ikpe amụma nke leukemia ma enwere ike iji ya buru amụma nlọghachi nke leukemia mgbe ọgwụgwọ gasịrị.