Mmadụ BCR-ABL Fusion Gene Mutation
Aha ngwaahịa
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Ngwa HWTS-GE016A-Freeze-akpọnwụ mmadụ BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Epidemiology
Myelogenousleukemia na-adịghị ala ala (CML) bụ ọrịa na-adịghị mma nke clonal nke mkpụrụ ndụ sel hematopoietic. Ihe karịrị 95% nke ndị ọrịa CML na-ebu chromosome Philadelphia (Ph) n'ime sel ọbara ha. Ihe na-ebutekarị ọrịa CML bụ nke a: A na-emepụta mkpụrụ ndụ BCR-ABL site na ntụgharị n'etiti abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) na ogwe aka ogologo nke chromosome 9 (9q34) na mpaghara nkwụsịtụ ụyọkọ (BCR) na ogologo ogwe aka nke chromosome 9 (9q34). protein fusion nke a na-etinye na mkpụrụ ndụ ihe nketa a nwere ọrụ tyrosine kinase (TK), ma mee ka ụzọ mgbaàmà ya dị n'okpuru (dịka RAS, PI3K, na JAK / STAT) iji kwalite nkewa cell na igbochi apoptosis cell, na-eme ka mkpụrụ ndụ na-amụbawanye nke ọma, ma si otú ahụ na-eme ka CML pụta. BCR-ABL bụ otu n'ime ihe nrịbama nchoputa dị mkpa nke CML. Mgbanwe dị egwu nke ọkwa ederede ya bụ ihe ngosi a pụrụ ịdabere na ya maka ikpe gbasara ọrịa leukemia ma nwee ike iji kọwaa nlọghachi nke ọrịa leukemia mgbe ọgwụgwọ gasịrị.
Ọwa
| FAM | Mkpụrụ ndụ ihe nketa BCR-ABL |
| VIC/HEX | Njikwa ime |
Nka nka
| Nchekwa | Mmiri: ≤-18℃ N'ọchịchịrị |
| Ndụ nchekwa | Mmiri: ọnwa 9 |
| Ụdị ụdị | Ihe atụ ụmị ọkpụkpụ |
| LoD | 1000 oyiri/ml |
| Nkọwapụta
| Enweghị mmeghari mmegharị na mkpụrụ ndụ ihe nketa ndị ọzọ TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, na PML-RARa |
| Ngwa ndị ọdabara | Ngwa Biosystem 7500 ezigbo oge PCR Sistemu Ngwa Biosystem 7500 Ngwa PCR ngwa ngwa ozugbo QuantStudio® 5 Sistemụ PCR ezigbo oge Sistemụ PCR SLAN-96P ezigbo oge Sistemụ PCR Real-Time LightCycler®480 Sistemụ nchọpụta PCR nke LineGene 9600 Plus MA-6000 Real-Time Quantitative Thermal Cycler BioRad CFX96 ezigbo oge PCR sistemụ BioRad CFX Opus 96 PCR ezigbo oge |
