Mmadụ BCR-ABL Fusion Gene Mutation

Nkọwa dị mkpirikpi:

Ngwa a dabara adaba maka nchọpụta qualitative nke p190, p210 na p230 isoforms nke BCR-ABL fusion gene na ụmị ọkpụkpụ mmadụ.


Nkọwa ngwaahịa

Mkpado ngwaahịa

Aha ngwaahịa

HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)

Epidemiology

Myelogenousleukemia na-adịghị ala ala (CML) bụ ọrịa na-adịghị mma nke clonal nke mkpụrụ ndụ sel hematopoietic.Ihe karịrị 95% nke ndị ọrịa CML na-ebu chromosome Philadelphia (Ph) n'ime sel ọbara ha.Ihe na-ebutekarị ọrịa CML bụ nke a: A na-emepụta mkpụrụ ndụ BCR-ABL site na ntụgharị n'etiti abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) na ogwe aka ogologo nke chromosome 9 (9q34) na mpaghara ụyọkọ breakpoint ( BCR) gene na ogologo ogwe aka nke chromosome 22 (22q11);protein fusion nke mkpụrụ ndụ ihe nketa a na-etinye na ya nwere ọrụ tyrosine kinase (TK), ma na-eme ka ụzọ mgbaàmà ya dị n'okpuru (dịka RAS, PI3K, na JAK/STAT) iji kwalite nkewa sel na igbochi apoptosis cell, na-eme ka mkpụrụ ndụ na-amụba nke ọma, ma si otú ahụ na-eme ka ọ dịkwuo njọ. ihe omume CML.BCR-ABL bụ otu n'ime ihe nrịbama nchoputa dị mkpa nke CML.Mgbanwe dị egwu nke ọkwa ederede ya bụ ihe ngosi a pụrụ ịdabere na ya maka ikpe gbasara ọrịa leukemia ma nwee ike iji kọwaa nlọghachi nke ọrịa leukemia mgbe ọgwụgwọ gasịrị.

Ọwa

FAM Mkpụrụ ndụ ihe nketa BCR-ABL
VIC/HEX Njikwa ime

Nka nka

Nchekwa Mmiri: ≤-18℃ N'ọchịchịrị
Ndụ nchekwa Mmiri: ọnwa 9
Ụdị ụdị Ihe atụ ụmị ọkpụkpụ
LoD 1000 oyiri/ml

Nkọwapụta

 

Enweghị mmeghari mmegharị na mkpụrụ ndụ ihe nketa ndị ọzọ TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, na PML-RARa
Ngwa ndị ọdabara Ngwa Biosystem 7500 ezigbo oge PCR Sistemu

Ngwa Biosystem 7500 Ngwa PCR ngwa ngwa ozugbo

QuantStudio® 5 Sistemụ PCR ezigbo oge

Sistemụ PCR SLAN-96P ezigbo oge

Sistemụ PCR Real-Time LightCycler®480

Sistemụ nchọpụta PCR nke LineGene 9600 Plus

MA-6000 Real-Time Quantitative Thermal Cycler

BioRad CFX96 ezigbo oge PCR sistemụ

BioRad CFX Opus 96 PCR ezigbo oge


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