Mmadụ ROS1 Fusion Gene Mutation

ROS1 bụ transmembrane tyrosine kinase nke ezinụlọ nnabata insulin. A kwadoro mkpụrụ ndụ ihe nketa ROS1 dị ka ihe ọzọ dị mkpa na-abụghị obere cell nke ọkwọ ụgbọ ala. Dị ka onye nnọchiteanya nke ọhụrụ pụrụ iche molekụla subtype, ihe omume nke ROS1 fusion gene na NSCLC Ihe dị ka 1% ka 2% ROS1 na-emezigharị mkpụrụ ndụ ihe nketa na exons 32, 34, 35 na 36. Mgbe ejiri ya na mkpụrụ ndụ ihe nketa dịka CD74, EZR, SLC34A2, ROS ga-anọgide na-arụ ọrụ kinDC1. mpaghara. ROS1 kinase na-arụ ọrụ na-adịghị mma nwere ike ime ka ụzọ mgbaàmà mgbada dị ka RAS/MAPK/ERK, PI3K/Akt/mTOR, na JAK3/STAT3, si otú a na-ekere òkè na mmụba, ọdịiche na metastasis nke mkpụrụ ndụ tumo, na-akpata ọrịa cancer. N'ime mmụgharị ROS1 fusion, CD74-ROS1 nwere ihe dị ka 42%, EZR bụ ihe dịka 15%, SLC34A2 bụ ihe dịka 12%, na SDC4 bụ ihe dịka 7%. Nnyocha egosiwo na saịtị ATP-binding nke catalytic ngalaba nke ROS1 kinase na ATP-binding saịtị nke ALK kinase nwere homology ruru 77%, ya mere ALK tyrosine kinase obere molecule inhibitor crizotinib na ihe ndị ọzọ nwere mmetụta ọgwụgwọ doro anya na ọgwụgwọ NSCLC na ngbanwe nke ROS1. Ya mere, nchọpụta ROS1 fusion mutations bụ ihe ndabere na ndabere maka nduzi iji ọgwụ crizotinib eme ihe.