Nchọpụta BCR-ABL dị mkpa maka ọgwụgwọ CML

Myelogenousleukemia na-adịghị ala ala (CML) bụ ọrịa na-adịghị mma nke clonal nke mkpụrụ ndụ sel hematopoietic. Ihe karịrị 95% nke ndị ọrịa CML na-ebu chromosome Philadelphia (Ph) n'ime sel ọbara ha. Na mkpụrụ ndụ ihe nketa BCR-ABL na-etolite site na ntụgharị n'etiti ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) na ogwe aka ogologo nke chromosome 9 (9q34) na mpaghara ụyọkọ breakpoint (BCR) na ogologo ogwe aka nke chromosome 22 (22q11). Ngwakọta protein ya jikọtara ya na mkpụrụ ndụ ihe nketa a nwere ọrụ tyrosine kinase (TK), ma na-eme ka ụzọ mgbaàmà ya dị n'okpuru (dịka RAS, PI3K, na JAK/STAT) iji kwalite nkewa cell na igbochi apoptosis cell, na-eme ka mkpụrụ ndụ na-amụba nke ọma, ma si otú a na-eme ka CML pụta.

BCR-ABL fusion gene, nke dị mkpa na mmepe nke CML, na-eje ozi dị ka isi ihe nrịbama nchọpụta. nke CML. Nchọpụta ya na-enyere aka nyochaa onye ọrịa's nzaghachi na tyrosine kinase inhibitors (TKIs) ma na-ebu amụma nlọghachi ọrịa leukemia, nke dị mkpa maka njikwa ọrịa CML dị irè.

BCR-ABL mmadụNgwa ihe nchọpụta mkpụrụ ndụ ihe nketasite na Macro & Micro-Test maka nchọpụta nke ọma nke BCR-ABL na ndị ọrịa CML, na-enyere aka nyocha CML ma na-eduzi ọgwụgwọ ụlọ ọgwụ ezubere iche iji kwalite usoro ọgwụgwọ maka njikwa ndị ọrịa dị irè.BCR-ABL fusion gene, nkebụmkpana mmepe nke CML,na-eje ozi dị ka isi ihe nrịbama nchọpụtaofCML. Nchọpụta ya na-enyere akanyochaandidi'sNzaghachi na ndị na-egbochi tyrosine kinase (TKIs)nana-ebu amụma nlọghachi ọrịa leukemia, nke budị mkpato dị irèCMLnjikwa ndị ọrịa.

Ngwa BCR-ABL Fusion Gene Mgbanwe Ihe Nchọpụta sitere na Macro & Micro-Test maka nchọpụta nke ọma nke BCR-ABL na ndị ọrịa CML, na-enyere akaCMLnchoputananduezubere iche maka ọgwụgwọ ụlọ ọgwụtobulie elueusoro ọgwụgwọ maka njikwa ndị ọrịa dị irè.

Nke zuru okeDechiche:N'otu ogenchọpụtamaka3mkpụrụ ndụ ihe nketa jikọrọ ọnụ (P210, P190, P230)makasara mbara mkpuchi namgbochi site na ikpe efu;

Mmetụta dị elu:Ụdị mmiri mmiri na-achọpụta mkpụrụ ndụ ihe nketa njikọna LoDnke 1000 oyiri/ml,na ụdị lyophilizedof 500 oyiri/ml;

Magburu onweAizi ezi: Inke etitinjikwana UNG enzyme iji gbochie ihe na-ezighị ezi&adịghị mma;

Ọrụ dị mfe na arụmọrụ:Arụ ọrụ tube mechiri emechi,free nke ngwaahịapost-processing,nanchọpụtan'imeNkeji 60makaebumnobi na a pụrụ ịdabere na ya pụta;

ỌzọNhọrọ:Ụdị Liquid na lyophilized maka nhọrọ ndị ahịa;

Ndakọrịta sara mbara:Dakọtara na ọtụtụ sistemụ PCR maka ịnweta ụlọ nyocha sara mbara.