Mgbanwe Mkpụrụ Ndụ Ihe nketa nke CYP2C9 na VKORC1 nke Mmadụ

Warfarin bụ ọgwụ mgbochi afọ nke a na-ejikarị eme ihe n'ọgwụgwọ ugbu a, nke a na-ejikarị eme ihe maka igbochi na ọgwụgwọ nke ọrịa thromboembolic. Agbanyeghị, warfarin nwere obere oge ọgwụgwọ ma dị iche iche n'etiti agbụrụ na ndị mmadụ n'otu n'otu. Ọnụọgụgụ egosila na ọdịiche nke dose kwụsiri ike na ndị mmadụ dị iche iche nwere ike ịbụ ihe karịrị ugboro 20. Ọbara mmeghachi omume ọjọọ na-eme na 15.2% nke ndị ọrịa na-aṅụ warfarin kwa afọ, nke 3.5% na-ebute ọbara ọgbụgba na-egbu egbu. Ọmụmụ ọgwụ egosila na polymorphism mkpụrụ ndụ ihe nketa nke enzyme ebumnuche VKORC1 na metabolic enzyme CYP2C9 nke warfarin bụ ihe dị mkpa na-emetụta ọdịiche dị na dose nke warfarin. Warfarin bụ ihe na-egbochi kpọmkwem vitamin K epoxide reductase (VKORC1), si otú a na-egbochi njikọ nke ihe na-eme ka coagulation dị n'ime vitamin K ma na-enye anticoagulation. Ọtụtụ ọmụmụ egosila na polymorphism mkpụrụ ndụ ihe nketa nke onye na-akwalite VKORC1 bụ ihe kachasị mkpa na-emetụta ọdịiche agbụrụ na nke onye ọ bụla na dose warfarin achọrọ. CYP2C9 na-eme ka Warfarin gbakee, mgbanwe ya na-ebelatakwa metabolism nke warfarin nke ukwuu. Ndị na-eji warfarin nwere nnukwu ihe ize ndụ nke ọbara ọgbụgba (ugboro abụọ ruo ugboro atọ karịa) na mbido ojiji.