Cyp2c9 na vkorc1 Gene Gene Polymorphism

Warfarin bụ anticogultant a na-ejikarị ya na omume ụlọ ọgwụ ugbu a, nke a na-ezubere maka mgbochi na ọgwụgwọ nke ọrịa cenmbolic. Agbanyeghị, Warfarin nwere windo a ga-eme ka dịgasị iche iche na ndị mmadụ. Statistics egosila na ọdịiche dị iche nke stable na mmadụ dị iche nwere ike ịbụ ihe karịrị ugboro 20. Ọgbụgba ọgbụgba na-egbu egbu na-aputa na 15.2% nke ndị ọrịa na-ewere warfarin kwa afọ, nke 3.5% na-eto ọbara ọbara. Ọmụmụ Photogenomic Studyy Polymorphism gosipụtara na mkpụrụ ndụ ihe mejupụtara enzyme Vkorc1 na metabolicle cyp2c9 nke Warfarin bụ ihe dị mkpa na-emetụta ọdịiche dị na dose nke Warfarin. Warfarin bụ onye a kapịrị ọnụ nke vitamin K na-emegharị (Vkorc1), ma si otú ahụ gbochie clotting Plantin na-enye anticọna. Ọnụ ọgụgụ buru ibu nke ọmụmụ ihe gosiri na ihe ngosi nke Vkorc1 bụ ihe kachasị mkpa na-emetụta agbụrụ na ọdịiche nke ọrụ Warfarin. Cyp2cin metabolinized nke Cyp2c9, ndị na-amụchi ya ji nwayọ nwayọ nke Warfarin. Ndị mmadụ na-eji Warfarin nwere ihe ize ndụ dị elu (ugboro abụọ ruo ugbu a) nke ọbara ọgbụgba na mbido ojiji.