Mmadụ CYP2C9 na VKORC1 Gene Polymorphism

Warfarin bụ ọgwụ mgbochi ọnụ nke a na-ejikarị eme ihe na ụlọ ọgwụ ugbu a, bụ nke e bu n'obi maka mgbochi na ọgwụgwọ ọrịa thromboembolic.Agbanyeghị, warfarin nwere windo ọgwụgwọ nwere oke ma dị iche iche n'etiti agbụrụ na ndị mmadụ n'otu n'otu.Statistics egosila na ọdịiche nke dose ahụ kwụsiri ike na ndị mmadụ dị iche iche nwere ike karịa ugboro 20.Ọbara ọgbụgba na-adịghị mma na-apụta na 15.2% nke ndị ọrịa na-ewere warfarin kwa afọ, nke 3.5% na-ebute ọbara ọgbụgba na-egbu egbu.Ọmụmụ ọgwụ ọgwụ egosila na mkpụrụ ndụ ihe nketa polymorphism nke lekwasịrị anya enzyme VKORC1 na enzyme metabolic CYP2C9 nke warfarin bụ ihe dị mkpa na-emetụta ọdịiche dị na dose nke warfarin.Warfarin bụ ihe mgbochi kpọmkwem nke vitamin K epoxide reductase (VKORC1), wee si otú a na-egbochi njikọ ihe na-akpata clotting nke gụnyere vitamin K ma na-enye ọgwụ mgbochi.Ọnụ ọgụgụ dị ukwuu nke ọmụmụ egosila na gene polymorphism nke VKORC1 onye na-akwalite bụ ihe kachasị mkpa na-emetụta agbụrụ na ọdịiche nke onye ọ bụla na ihe achọrọ nke warfarin.Warfarin bụ metabolized site na CYP2C9, na mutants ya na-eji nwayọọ nwayọọ na-ebelata metabolism nke warfarin.Ndị mmadụ n'otu n'otu na-eji warfarin nwere nnukwu ihe ize ndụ dị elu (ugboro abụọ ruo okpukpu atọ) nke ọbara ọgbụgba na mmalite nke ojiji.